Computational analysis of long-range allosteric communications in CFTR
Ayca Ersoy, Bengi Altintel, Nurit Livnat Levanon, Nir Ben-Tal, Turkan Haliloglu, Oded Lewinson. eLife 2023
Listeria monocytogenes TcyKLMN Cystine/Cysteine Transporter Facilitates Glutathione Synthesis and Virulence Gene Expression
Brenner M, Friedman S, Haber A, Livnat-Levanon N, Borovok I, Sigal N, Lewinson O, Herskovits AA. mBio. 2022
The copper-linked Escherichia coli AZY operon: Structure, metal binding, and a possible physiological role in copper delivery
Hadley RC, Zhitnitsky D, Livnat-Levanon N, Masrati G, Vigonsky E, Rose J, Ben-Tal N, Rosenzweig AC, Lewinson O. J Biol Chem. 2022
Titratable transmembrane residues and a hydrophobic plug are essential for manganese import via the Bacillus anthracis ABC transporter MntBC-A
Kuznetsova A, Masrati G, Vigonsky E, Livnat-Levanon N, Rose J, Grupper M, Baloum A, Yang JG, Rees DC, Ben-Tal N, Lewinson O. J Biol Chem. 2022
Identification of conserved slow codons that are important for protein expression and function
Perach M, Zafrir Z, Tuller T, Lewinson O. RNA Biol. 2021
Structures of ABC transporters: handle with care
Lewinson O, Orelle C, Seeger MA. FEBS Lett. 2020.
Structural and functional diversity calls for a new classification of ABC transporters
Thomas C, Aller SG, Beis K, Carpenter EP, Chang G, Chen L, Dassa E, Dean M, Duong Van Hoa F, Ekiert D, Ford R, Gaudet R, Gong X, Holland IB, Huang Y, Kahne DK, Kato H, Koronakis V, Koth CM, Lee Y, Lewinson O, Lill R, Martinoia E, Murakami S, Pinkett HW, Poolman B, Rosenbaum D, Sarkadi B, Schmitt L, Schneider E, Shi Y, Shyng SL, Slotboom DJ, Tajkhorshid E, Tieleman DP, Ueda K, Váradi A, Wen PC, Yan N, Zhang P, Zheng H, Zimmer J, Tampé R. FEBS Lett. 2020.
Single-molecule probing of the conformational homogeneity of the ABC transporter BtuCD
Yang M, Livnat Levanon N, Acar B, Aykac Fas B, Masrati G, Rose J, Ben-Tal N, Haliloglu T, Zhao Y, Lewinson O. Nat Chem Biol. 2018.
Distinct Allosteric Networks Underlie Mechanistic Speciation of ABC Transporters
Acar B, Rose J, Aykac Fas B, Ben-Tal N, Lewinson O, Haliloglu T. Structure. 2020.
Substrate recognition and ATPase activity of the E. coli cysteine/cystine ABC transporter YecSC-FliY
Sabrialabed S, Yang JG, Yariv E, Ben-Tal N, Lewinson O. J Biol Chem. 2020.
Dimerization of the adaptor Gads facilitates antigen receptor signaling by promoting the cooperative binding of Gads to the adaptor LAT
Sukenik S, Frushicheva MP, Waknin-Lellouche C, Hallumi E, Ifrach T, Shalah R, Beach D, Avidan R, Oz I, Libman E, Aronheim A, Lewinson O, Yablonski D. Sci Signal. 2017.
ATP binding and hydrolysis disrupt the high-affinity interaction between the heme ABC transporter HmuUV and its cognate substrate-binding protein
Qasem-Abdullah H, Perach M, Livnat-Levanon N, Lewinson O. J Biol Chem. 2017
The highly synergistic, broad spectrum, antibacterial activity of organic acids and transition metals
Zhitnitsky D, Rose J, Lewinson O. Sci Rep. 2017.
L-glutamine Induces Expression of Listeria monocytogenes Virulence Genes
Haber A, Friedman S, Lobel L, Burg-Golani T, Sigal N, Rose J, Livnat-Levanon N, Lewinson O, Herskovits AA. PLoS Pathog. 2017.
Mechanism of Action of ABC Importers: Conservation, Divergence, and Physiological Adaptations
Lewinson O, Livnat-Levanon N. J Mol Biol. 2017.
The uncoupled ATPase activity of the ABC transporter BtuC2D2 leads to a hysteretic conformational change, conformational memory, and improved activity
Livnat-Levanon N, I Gilson A, Ben-Tal N, Lewinson O. Sci Rep. 2016.
Metal binding spectrum and model structure of the Bacillus anthracis virulence determinant MntA
Vigonsky E, Fish I, Livnat-Levanon N, Ovcharenko E, Ben-Tal N, Lewinson O. Metallomics. 2015.
Real time measurements of membrane protein:receptor interactions using Surface Plasmon Resonance (SPR).
Livnat Levanon N, Vigonsky E, Lewinson O. J Vis Exp. 2014.
A relay network of extracellular heme-binding proteins drives C. albicans iron acquisition from hemoglobin
Kuznets G, Vigonsky E, Weissman Z, Lalli D, Gildor T, Kauffman SJ, Turano P, Becker J, Lewinson O, Kornitzer D. PLoS Pathog. 2014.
Structural basis for heavy metal detoxification by an Atm1-type ABC exporter
Lee JY, Yang JG, Zhitnitsky D, Lewinson O, Rees DC. Science. 2014.
Identification of functionally important conserved trans-membrane residues of bacterial PIB -type ATPases
Zhitnitsky D, Lewinson O. Mol Microbiol. 2014.
A single intact ATPase site of the ABC transporter BtuCD drives 5% transport activity yet supports full in vivo vitamin B12 utilization
Tal N, Ovcharenko E, Lewinson O. Proc Natl Acad Sci U S A. 2013.
Two molybdate/tungstate ABC transporters that interact very differently with their substrate binding proteins
Vigonsky E, Ovcharenko E, Lewinson O. Proc Natl Acad Sci U S A. 2013.
The size of the proteasomal substrate determines whether its degradation will be mediated by mono- or polyubiquitylation
Shabek N, Herman-Bachinsky Y, Buchsbaum S, Lewinson O, Haj-Yahya M, Hejjaoui M, Lashuel HA, Sommer T, Brik A, Ciechanover A. Mol Cell. 2012.
Bacterial ATP-driven transporters of transition metals: physiological roles, mechanisms of action, and roles in bacterial virulence
Klein JS, Lewinson O. Metallomics. 2011.
Previous publications
A distinct mechanism for the ABC transporter BtuCD-BtuF revealed by the dynamics of complex formation
Lewinson O, Lee AT, Locher KP, Rees DC. Nat Struct Mol Biol. 2010.
A P-type ATPase importer that discriminates between essential and toxic transition metals
Lewinson O, Lee AT, Rees DC. Proc Natl Acad Sci U S A. 2009.
ABC transporters: the power to change
Rees DC, Johnson E, Lewinson O. Nat Rev Mol Cell Biol. 2009.
The funnel approach to the precrystallization production of membrane proteins
Lewinson O, Lee AT, Rees DC. J Mol Biol. 2008.
E. coli multidrug transporter MdfA is a monomer
Sigal N, Lewinson O, Wolf SG, Bibi E. Biochemistry. 2007.
Promiscuity in multidrug recognition and transport: the bacterial MFS Mdr transporters
Lewinson O, Adler J, Sigal N, Bibi E. Mol Microbiol. 2006.
Do physiological roles foster persistence of drug/multidrug-efflux transporters? A case study
Krulwich TA, Lewinson O, Padan E, Bibi E. Nat Rev Microbiol. 2005.
Alkalitolerance: a biological function for a multidrug transporter in pH homeostasis
Lewinson O, Padan E, Bibi E. Proc Natl Acad Sci U S A. 2004.
Role of a conserved membrane-embedded acidic residue in the multidrug transporter MdfA
Adler J, Lewinson O, Bibi E. Biochemistry. 2004.
The Escherichia coli multidrug transporter MdfA catalyzes both electrogenic and electroneutral transport reactions
Lewinson O, Adler J, Poelarends GJ, Mazurkiewicz P, Driessen AJ, Bibi E. Proc Natl Acad Sci U S A. 2003.
Evidence for simultaneous binding of dissimilar substrates by the Escherichia coli multidrug transporter MdfA
Lewinson O, Bibi E. Biochemistry. 2001.
MdfA, an interesting model protein for studying multidrug transport.
Bibi E, Adler J, Lewinson O, Edgar R. J Mol Microbiol Biotechnol. 2001.