Listeria monocytogenes TcyKLMN Cystine/Cysteine Transporter Facilitates Glutathione Synthesis and Virulence Gene Expression

Brenner M, Friedman S, Haber A, Livnat-Levanon N, Borovok I, Sigal N, Lewinson O, Herskovits AA. mBio. 2022

The copper-linked Escherichia coli AZY operon: Structure, metal binding, and a possible physiological role in copper delivery

Hadley RC, Zhitnitsky D, Livnat-Levanon N, Masrati G, Vigonsky E, Rose J, Ben-Tal N, Rosenzweig AC, Lewinson O. J Biol Chem. 2022

Titratable transmembrane residues and a hydrophobic plug are essential for manganese import via the Bacillus anthracis ABC transporter MntBC-A

Kuznetsova A, Masrati G, Vigonsky E, Livnat-Levanon N, Rose J, Grupper M, Baloum A, Yang JG, Rees DC, Ben-Tal N, Lewinson O. J Biol Chem. 2022

Identification of conserved slow codons that are important for protein expression and function

Perach M, Zafrir Z, Tuller T, Lewinson O. RNA Biol. 2021

Structures of ABC transporters: handle with care

Lewinson O, Orelle C, Seeger MA. FEBS Lett. 2020.

Structural and functional diversity calls for a new classification of ABC transporters

Thomas C, Aller SG, Beis K, Carpenter EP, Chang G, Chen L, Dassa E, Dean M, Duong Van Hoa F, Ekiert D, Ford R, Gaudet R, Gong X, Holland IB, Huang Y, Kahne DK, Kato H, Koronakis V, Koth CM, Lee Y, Lewinson O, Lill R, Martinoia E, Murakami S, Pinkett HW, Poolman B, Rosenbaum D, Sarkadi B, Schmitt L, Schneider E, Shi Y, Shyng SL, Slotboom DJ, Tajkhorshid E, Tieleman DP, Ueda K, Váradi A, Wen PC, Yan N, Zhang P, Zheng H, Zimmer J, Tampé R. FEBS Lett. 2020.

Single-molecule probing of the conformational homogeneity of the ABC transporter BtuCD

Yang M, Livnat Levanon N, Acar B, Aykac Fas B, Masrati G, Rose J, Ben-Tal N, Haliloglu T, Zhao Y, Lewinson O. Nat Chem Biol. 2018.

Distinct Allosteric Networks Underlie Mechanistic Speciation of ABC Transporters

Acar B, Rose J, Aykac Fas B, Ben-Tal N, Lewinson O, Haliloglu T. Structure. 2020.

Substrate recognition and ATPase activity of the E. coli cysteine/cystine ABC transporter YecSC-FliY

Sabrialabed S, Yang JG, Yariv E, Ben-Tal N, Lewinson O. J Biol Chem. 2020.

Dimerization of the adaptor Gads facilitates antigen receptor signaling by promoting the cooperative binding of Gads to the adaptor LAT

Sukenik S, Frushicheva MP, Waknin-Lellouche C, Hallumi E, Ifrach T, Shalah R, Beach D, Avidan R, Oz I, Libman E, Aronheim A, Lewinson O, Yablonski D. Sci Signal. 2017.

ATP binding and hydrolysis disrupt the high-affinity interaction between the heme ABC transporter HmuUV and its cognate substrate-binding protein

Qasem-Abdullah H, Perach M, Livnat-Levanon N, Lewinson O. J Biol Chem. 2017

The highly synergistic, broad spectrum, antibacterial activity of organic acids and transition metals

Zhitnitsky D, Rose J, Lewinson O. Sci Rep. 2017.

L-glutamine Induces Expression of Listeria monocytogenes Virulence Genes

Haber A, Friedman S, Lobel L, Burg-Golani T, Sigal N, Rose J, Livnat-Levanon N, Lewinson O, Herskovits AA. PLoS Pathog. 2017.

Mechanism of Action of ABC Importers: Conservation, Divergence, and Physiological Adaptations

Lewinson O, Livnat-Levanon N. J Mol Biol. 2017.

The uncoupled ATPase activity of the ABC transporter BtuC2D2 leads to a hysteretic conformational change, conformational memory, and improved activity

Livnat-Levanon N, I Gilson A, Ben-Tal N, Lewinson O. Sci Rep. 2016.

Metal binding spectrum and model structure of the Bacillus anthracis virulence determinant MntA

Vigonsky E, Fish I, Livnat-Levanon N, Ovcharenko E, Ben-Tal N, Lewinson O. Metallomics. 2015.

Real time measurements of membrane protein:receptor interactions using Surface Plasmon Resonance (SPR).

Livnat Levanon N, Vigonsky E, Lewinson O. J Vis Exp. 2014.

A relay network of extracellular heme-binding proteins drives C. albicans iron acquisition from hemoglobin

Kuznets G, Vigonsky E, Weissman Z, Lalli D, Gildor T, Kauffman SJ, Turano P, Becker J, Lewinson O, Kornitzer D. PLoS Pathog. 2014.

 Structural basis for heavy metal detoxification by an Atm1-type ABC exporter

Lee JY, Yang JG, Zhitnitsky D, Lewinson O, Rees DC. Science. 2014.

Identification of functionally important conserved trans-membrane residues of bacterial PIB -type ATPases

Zhitnitsky D, Lewinson O. Mol Microbiol. 2014.

A single intact ATPase site of the ABC transporter BtuCD drives 5% transport activity yet supports full in vivo vitamin B12 utilization

Tal N, Ovcharenko E, Lewinson O. Proc Natl Acad Sci U S A. 2013.

Two molybdate/tungstate ABC transporters that interact very differently with their substrate binding proteins

Vigonsky E, Ovcharenko E, Lewinson O. Proc Natl Acad Sci U S A. 2013.

The size of the proteasomal substrate determines whether its degradation will be mediated by mono- or polyubiquitylation

Shabek N, Herman-Bachinsky Y, Buchsbaum S, Lewinson O, Haj-Yahya M, Hejjaoui M, Lashuel HA, Sommer T, Brik A, Ciechanover A. Mol Cell. 2012.

Bacterial ATP-driven transporters of transition metals: physiological roles, mechanisms of action, and roles in bacterial virulence

Klein JS, Lewinson O. Metallomics. 2011.

Previous publications

A distinct mechanism for the ABC transporter BtuCD-BtuF revealed by the dynamics of complex formation

Lewinson O, Lee AT, Locher KP, Rees DC. Nat Struct Mol Biol. 2010.

A P-type ATPase importer that discriminates between essential and toxic transition metals

Lewinson O, Lee AT, Rees DC. Proc Natl Acad Sci U S A. 2009.

ABC transporters: the power to change

Rees DC, Johnson E, Lewinson O. Nat Rev Mol Cell Biol. 2009.

The funnel approach to the precrystallization production of membrane proteins

Lewinson O, Lee AT, Rees DC. J Mol Biol. 2008.

E. coli multidrug transporter MdfA is a monomer

Sigal N, Lewinson O, Wolf SG, Bibi E. Biochemistry. 2007.

Promiscuity in multidrug recognition and transport: the bacterial MFS Mdr transporters

Lewinson O, Adler J, Sigal N, Bibi E. Mol Microbiol. 2006.

Do physiological roles foster persistence of drug/multidrug-efflux transporters? A case study

Krulwich TA, Lewinson O, Padan E, Bibi E. Nat Rev Microbiol. 2005.

Alkalitolerance: a biological function for a multidrug transporter in pH homeostasis

Lewinson O, Padan E, Bibi E. Proc Natl Acad Sci U S A. 2004.

Role of a conserved membrane-embedded acidic residue in the multidrug transporter MdfA

Adler J, Lewinson O, Bibi E. Biochemistry. 2004.

The Escherichia coli multidrug transporter MdfA catalyzes both electrogenic and electroneutral transport reactions

Lewinson O, Adler J, Poelarends GJ, Mazurkiewicz P, Driessen AJ, Bibi E. Proc Natl Acad Sci U S A. 2003.

Evidence for simultaneous binding of dissimilar substrates by the Escherichia coli multidrug transporter MdfA

Lewinson O, Bibi E. Biochemistry. 2001.

MdfA, an interesting model protein for studying multidrug transport.

Bibi E, Adler J, Lewinson O, Edgar R. J Mol Microbiol Biotechnol. 2001.